Article
T helper 17 cells play a critical pathogenic role in lung cancer.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2014
Chang Seon Hee, Mirabolfathinejad Seyedeh Golsar, Katta Harshadadevi, Cumpian Amber M, Gong Lei, Caetano Mauricio S, Moghaddam Seyed Javad, Dong Chen
Abstract excerpt
Lung cancer development is associated with extensive pulmonary inflammation. In addition, the linkage between chronic obstructive pulmonary disease (COPD) and lung cancer has been demonstrated in population-based studies. IL-17-producing CD4 helper T cells (Th17 cells) play a critical role in promoting chronic tissue inflammation. Although Th17 cells are found in human COPD and lung cancer, their role is not...
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