Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: gender-dependent modulation of IL-10 haploinsufficiency.

Molecular carcinogenesis - 1 Nov 2003

Bernert Heike, Sekikawa Kenji, Radcliffe Richard A, Iraqi Fuad, You Ming, Malkinson Alvin M

Abstract excerpt

Epidemiologic evidence suggests that pulmonary diseases with a prominent chronic inflammatory component elevate lung cancer risk. Genetic manipulations of mouse models of lung inflammation and tumorigenesis can be used to investigate this association. The genes encoding pro-inflammatory tumor necrosis factor-alpha (TNFalpha) and antiinflammatory IL-10 cytokines map within quantitative trait loci that regulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weight
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Homozygote

Share to Interleukin-10

Share to Sex Distribution

Share to Tumor Necrosis Factor-alpha

Share to Urethane

Source

Identifiers

PMID: 14587096
DOI: 10.1002/mc.10151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: gender-dependent modulation of IL-10 haploinsufficiency.PMID 14587096Read ↗

Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response.Semantic proximity Read ↗

Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities.Semantic proximity Read ↗

Quantitative trait locus mapping of susceptibilities to butylated hydroxytoluene-induced lung tumor promotion and pulmonary inflammation in CXB mice.Semantic proximity Read ↗

Genetic linkage analysis identifies Pas1 as the common locus modulating lung tumorigenesis and acute inflammatory response in mice.Semantic proximity Read ↗

Inflammatory Gene Polymorphisms in Lung Cancer Susceptibility.Semantic proximity Read ↗

Systematic evaluation of genetic variants in the inflammation pathway and risk of lung cancer.Semantic proximity Read ↗

Relationship between Lung Carcinogenesis and Chronic Inflammation in RodentsSemantic proximity Read ↗

Transcriptome of normal lung distinguishes mouse lines with different susceptibility to inflammation and to lung tumorigenesis.Semantic proximity Read ↗

Complex genetic control of lung tumorigenesis in resistant mice strains.Semantic proximity Read ↗

Lung tumor susceptibility in mice: an overview.Semantic proximity Read ↗

Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.Semantic proximity Read ↗

Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.