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Article

Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis.

Cancer research - 15 Jan 2008

Yusuf Nabiha, Nasti Tahseen H, Long J Alan, Naseemuddin Mohammed, Lucas Alan P, Xu Hui, Elmets Craig A

Abstract excerpt

Toll-like receptors (TLR) activate multiple steps in inflammatory reactions in innate immune responses. They also activate signals that are critically involved in the initiation of adaptive immune responses. Many tumorigenic chemicals have been associated with endotoxin hypersensitivity mediated through TLR4. To determine the role of TLR4 in cutaneous skin carcinogenesis, we treated TLR4-deficient C3H/HeJ mice...

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Source

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Identifiers

PMID: 18199559
DOI: 10.1158/0008-5472.CAN-07-5219
PMCID: PMC3568948

Genes

TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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