Article
K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation.
Anticancer research - 1 Sept 2011
Keohavong Phouthone, Kahkonen Beth, Kinchington Edwina, Yin Jinling, Jin Jide, Liu Xiaoping, Siegfried Jill M, DI Y Peter
Abstract excerpt
BACKGROUND: Chronic lung inflammation has been associated with an increased risk of lung cancer. However, it is unclear whether such an event affects the incidence of mutations in the K-ras oncogene frequently found in lung tumors and suggested to be involved in lung tumorigenesis. This study investigated potential impacts of inflammation on the incidence of lung tumors and K-ras mutations using a mouse model....
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