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Article

Enhanced phenotypic alterations of alveolar type II cells in response to Aflatoxin G1 -induced lung inflammation.

Journal of cellular physiology - 1 Jun 2015

Shen Haitao, Liu Chunping, Shao Peilu, Yi Li, Wang Yuan, Mills Ko Emily, Tian Ziqiang, Zhao Xin, Wang Juan, Xing Lingxiao, Zhang Xianghong

Abstract excerpt

Recently, we discovered that Aflatoxin G1 (AFG1 ) induces chronic lung inflammatory responses, which may contribute to lung tumorigenesis in Balb/C mice. The cancer cells originate from alveolar type II cells (AT-II cells). The activated AT-II cells express high levels of MHC-II and COX-2, may exhibit altered phenotypes, and likely inhibit antitumor immunity by triggering regulatory T cells (Tregs). However, the...

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PMID: 25336278
DOI: 10.1002/jcp.24852

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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