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Article

Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis.

Journal of the National Cancer Institute - 7 Dec 2005

Bauer Alison K, Dixon Darlene, DeGraff Laura M, Cho Hye-Youn, Walker Christopher R, Malkinson Alvin M, Kleeberger Steven R

Abstract excerpt

Because chronic pulmonary diseases predispose to lung neoplasia, the identification of the molecular mechanisms involved could provide novel preventive, diagnostic, and therapeutic strategies. Toll-like receptors (TLRs) transduce exogenous and endogenous signals into the production of inflammatory cytokines to coordinate adaptive immune responses. To determine the role of Tlr4 in chronic lung inflammation, we...

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Identifiers

PMID: 16333033
DOI: 10.1093/jnci/dji403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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