Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mendelian Randomization With Longitudinal Exposure Data: Simulation Study and Real Data Application.

Statistics in medicine - 1 Jan 2026

Pott Janne, Palma Marco, Liu Yi, Mack Jasmine A, Sovio Ulla, Smith Gordon C S, Barrett Jessica, Burgess Stephen

Abstract excerpt

BACKGROUND AND AIM: Mendelian randomization (MR) is a widely used tool to estimate causal effects using genetic variants as instrumental variables. MR is limited to cross-sectional summary statistics of different samples and time points to analyze time-varying effects. We aimed at using longitudinal summary statistics for an exposure in a multivariable MR setting and validating the effect estimates for the mean,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Longitudinal Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mendelian Randomization Analysis

Share to Models, Statistical

Share to Polymorphism, Single Nucleotide

Share to Regression Analysis

Share to UK Biobank

Source

Open in PubMed Open full text

Identifiers

PMID: 41567108
DOI: 10.1002/sim.70378
PMCID: PMC12824831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mendelian Randomization With Longitudinal Exposure Data: Simulation Study and Real Data Application.PMID 41567108Read ↗

Benchmarking Mendelian randomization methods for causal inference using genome-wide association study summary statistics.Semantic proximity Read ↗

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants.Semantic proximity Read ↗

Usefulness of Mendelian randomization in observational epidemiology.Semantic proximity Read ↗

[Mendelian randomization approach, used for causal inferences].Semantic proximity Read ↗

Mendelian Randomization.Semantic proximity Read ↗

A Guide to Understanding Mendelian Randomization StudiesSemantic proximity Read ↗

The use of two-sample methods for Mendelian randomization analyses on single large datasets.Semantic proximity Read ↗

Mendelian randomization: genetic anchors for causal inference in epidemiological studies.Semantic proximity Read ↗

Efficient Mendelian randomization analysis with self-adaptive determination of sample structure and multiple pleiotropic effects.Semantic proximity Read ↗

Mendelian randomization in (epi)genetic epidemiology: an effective tool to be handled with care.Semantic proximity Read ↗

Mendelian randomization: A powerful method to determine causality of biomarkers in diseasesSemantic proximity Read ↗

Mendelian Randomization as an Approach to Assess Causality Using Observational DataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.