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Limits to Causal Inference based on Mendelian Randomization: A Comparison with Randomized Controlled Trials

12 Jan 2006

Abstract excerpt

"Mendelian randomization" refers to the random assortment of genes transferred from parent to offspring at the time of gamete formation. This process has been compared to a randomized controlled trial of genetic variants. This could greatly aid observational epidemiology by potentially allowing an unbiased estimate of the effects of gene products on disease outcomes. However, studies utilizing Mendelian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16410347
DOI: 10.1093/aje/kwj062

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