Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenylketonuria: Direct and indirect effects of phenylalanine.

Experimental neurology - 1 Jul 2016

Schlegel Gudrun, Scholz Ralf, Ullrich Kurt, Santer René, Rune Gabriele M

Abstract excerpt

High phenylalanine concentrations in the brain due to dysfunctional phenylalanine hydroxylase (Pah) are considered to account for mental retardation in phenylketonuria (PKU). In this study, we treated hippocampal cultures with the amino acid in order to determine the role of elevated levels of phenylalanine in PKU-related mental retardation. Synapse density and dendritic length were dramatically reduced in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendrites
Share to Entorhinal Cortex
Share to Excitatory Amino Acid Agonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to N-Methylaspartate

Share to Phenylalanine

Share to Phenylalanine Hydroxylase

Share to Phenylketonurias

Share to rac1 GTP-Binding Protein

Source

Identifiers

PMID: 27091224
DOI: 10.1016/j.expneurol.2016.04.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenylketonuria: Direct and indirect effects of phenylalanine.PMID 27091224Read ↗

Evidence for central nervous system glial cell plasticity in phenylketonuria.Semantic proximity Read ↗

Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse.Semantic proximity Read ↗

Differential effects of low-phenylalanine protein sources on brain neurotransmitters and behavior in C57Bl/6-Pah(enu2) mice.Semantic proximity Read ↗

Critical time window of neuronal cholesterol synthesis during neurite outgrowth.Semantic proximity Read ↗

Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome.Semantic proximity Read ↗

Pathologic and immunohistochemical findings in hypothalamic and mesencephalic regions in the pah(enu2) mouse model for phenylketonuria.Semantic proximity Read ↗

The PICO Study: Impact of Phenylalanine on Cognitive, Cerebral and Neurometabolic Parameters in Adult Patients with Phenylketonuria: a Randomized, Placebo-Controlled, Crossover, Non-inferiority TrialSemantic proximity Read ↗

A Specific Nutrient Combination Attenuates the Reduced Expression of PSD-95 in the Proximal Dendrites of Hippocampal Cell Body Layers in a Mouse Model of Phenylketonuria.Semantic proximity Read ↗

Cognitive deficits in a genetic mouse model of the most common biochemical cause of human mental retardation.Semantic proximity Read ↗

Intellectual, neurologic, and neuropsychologic outcome in untreated subjects with nonphenylketonuria hyperphenylalaninemia. German Collaborative Study on Phenylketonuria.Semantic proximity Read ↗

Cerebral protein synthesis in a genetic mouse model of phenylketonuria.Semantic proximity Read ↗

Epilepsy in phenylketonuria: a complex dependence on serum phenylalanine levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.