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Article

Cognitive deficits in a genetic mouse model of the most common biochemical cause of human mental retardation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jul 1999

Zagreda L, Goodman J, Druin D P, McDonald D, Diamond A

Abstract excerpt

Phenylalanine hydroxylase (Pah)-deficient "PKU mice" have a mutation in the Pah gene that causes phenylketonuria (PKU) in humans. PKU produces cognitive deficits in humans if it is untreated. We report here the first evidence that the genetic mouse model of PKU (Pah(enu2)) also produces cognitive impairments. PKU mice were impaired on both odor discrimination reversal and latent learning compared with...

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Identifiers

PMID: 10407053
PMCID: PMC6783085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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