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Article

Critical time window of neuronal cholesterol synthesis during neurite outgrowth.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 May 2012

Fünfschilling Ursula, Jockusch Wolf J, Sivakumar Nandhini, Möbius Wiebke, Corthals Kristina, Li Sai, Quintes Susanne, Kim Younghoon, Schaap Iwan A T, Rhee Jeong-Seop, Nave Klaus-Armin, Saher Gesine

Abstract excerpt

Cholesterol is an essential membrane component enriched in plasma membranes, growth cones, and synapses. The brain normally synthesizes all cholesterol locally, but the contribution of individual cell types to brain cholesterol metabolism is unknown. To investigate whether cortical projection neurons in vivo essentially require cholesterol biosynthesis and which cell types support neurons, we have conditionally...

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Identifiers

PMID: 22649242
DOI: 10.1523/JNEUROSCI.1352-11.2012
PMCID: PMC6703588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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