Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cerebral protein synthesis in a genetic mouse model of phenylketonuria.

Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2000

Smith C B, Kang J

Abstract excerpt

Local rates of cerebral protein synthesis (lCPS(leu)) were measured with the quantitative autoradiographic [1-(14)C]leucine method in a genetic mouse model (Pah(enu2)) of phenylketonuria. As in the human disease, Pah(enu2) mice have a mutation in the gene for phenylalanine hydroxylase. We compared adult homozygous (HMZ) and heterozygous (HTZ) Pah(enu2) mice with the background strain (BTBR). Arterial plasma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Disease Models, Animal
Share to Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homozygote

Share to Nerve Tissue Proteins

Share to Phenylalanine Hydroxylase

Share to Phenylketonurias

Source

Open in PubMed Open full text

Identifiers

PMID: 11005872
DOI: 10.1073/pnas.97.20.11014
PMCID: PMC27140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cerebral protein synthesis in a genetic mouse model of phenylketonuria.PMID 11005872Read ↗

Deficits in brain serotonin synthesis in a genetic mouse model of phenylketonuria.Semantic proximity Read ↗

Phenylketonuria: modelling cerebral amino acid and neurotransmitter metabolismSemantic proximity Read ↗

Differential effects of low-phenylalanine protein sources on brain neurotransmitters and behavior in C57Bl/6-Pah(enu2) mice.Semantic proximity Read ↗

A heteroallelic mutant mouse model: A new orthologue for human hyperphenylalaninemia.Semantic proximity Read ↗

High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU).Semantic proximity Read ↗

Phenylketonuria: Direct and indirect effects of phenylalanine.Semantic proximity Read ↗

Inherited disturbances of phenylalanine metabolic kinetics in essential hypertension.Semantic proximity Read ↗

Epilepsy in phenylketonuria: a complex dependence on serum phenylalanine levels.Semantic proximity Read ↗

Confirmation of Decreased Rates of Cerebral Protein Synthesis In Vivo in a Mouse Model of Tuberous Sclerosis Complex.Semantic proximity Read ↗

Tetrahydrobiopterin protects phenylalanine hydroxylase activity in vivo: Implications for tetrahydrobiopterin‐responsive hyperphenylalaninemiaSemantic proximity Read ↗

Phenylalanine metabolism in a dilute-lethal strain of mice.Semantic proximity Read ↗

Variability of blood-brain ratios of phenylalanine in typical patients with phenylketonuria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.