Article

The PICO Study: Impact of Phenylalanine on Cognitive, Cerebral and Neurometabolic Parameters in Adult Patients with Phenylketonuria: a Randomized, Placebo-Controlled, Crossover, Non-inferiority Trial

2019-12-05

Abstract excerpt

<title>Abstract</title> <p>Background The population of adult patients with early-treated phenylketonuria (PKU) following newborn screening is growing substantially. The ideal target range of blood Phenylalanine (Phe) levels in adults outside pregnancy is a matter of debate. Therefore, prospective intervention studies are needed to evaluate the effects of an elevated Phe concentration on cognition and structural,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1e020db0-7fd2-523a-9ef7-0e3c0aa844c1
DOI: 10.21203/rs.2.9834/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The PICO Study: Impact of Phenylalanine on Cognitive, Cerebral and Neurometabolic Parameters in Adult Patients with Phenylketonuria: a Randomized, Placebo-Controlled, Crossover, Non-inferiority TrialDOI 10.21203/rs.2.9834/v2Read

What we know that could influence future treatment of phenylketonuria.Semantic proximity Read

The Effect of Improved Dietary Control on Cognitive and Psychiatric Functioning in Adults With Phenylketonuria: The ReDAPT StudySemantic proximity Read

Phenylalanine Effects on Brain Function in Adult PhenylketonuriaSemantic proximity Read

Phenylketonuria, co‐morbidity, and ageing: A reviewSemantic proximity Read

Nutritional and Therapeutic Strategies in Paediatric Phenylketonuria: A Narrative Literature ReviewSemantic proximity Read

Cognitive profile and mental health in adult phenylketonuria: A PKU-COBESO study.Semantic proximity Read

Phenylketonuria: modelling cerebral amino acid and neurotransmitter metabolismSemantic proximity Read

Neuropsychologic functions of early treated patients with phenylketonuria, on and off diet: results of a cross-national and cross-sectional study.Semantic proximity Read

Development of the Executive Function, Attention, and Speed Symptom Inventory (EASSI) for PhenylketonuriaSemantic proximity Read

Exploring Subpopulations for Epidemiological Precision Nutrition Research: The Example of Phenylalanine Hydroxylase (PAH) Genetic Variation.Semantic proximity Read

Intellectual, neurologic, and neuropsychologic outcome in untreated subjects with nonphenylketonuria hyperphenylalaninemia. German Collaborative Study on Phenylketonuria.Semantic proximity Read