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The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance

4 Sept 2018

Abstract excerpt

Autoimmune regulator (AIRE), whose gene mutation is considered to be a causative factor of autoimmune polyglandular syndrome type 1 (APS1), is an important transcriptional regulator. Studies on the role of AIRE in the central immune system have demonstrated that AIRE can eliminate autoreactive T cells by regulating the expression of a series of tissue specific antigens promiscuously in medullary thymic epithelial...

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PMID: 30255105
DOI: 10.1155/2018/3930750

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