Article
Alterations of the autoimmune regulator transcription factor and failure of central tolerance: APECED as a model.
Expert review of clinical immunology - 1 Jan 2013
Gallo Vera, Giardino Giuliana, Capalbo Donatella, Palamaro Loredana, Romano Rosa, Santamaria Francesca, Maio Filomena, Salerno Mariacarolina, Vajro Pietro, Pignata Claudio
Abstract excerpt
Self-nonself discrimination plays a key role in inducing a productive immunity and in preventing autoimmune reactions. Central tolerance within the thymus and peripheral tolerance in peripheral lymphoid organs lead to immunologic nonresponsiveness against self-components. The central tolerance represents the mechanism by which T cells binding with high avidity to self-antigens are eliminated through the so-called...
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