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Article

Update on Aire and thymic negative selection.

Immunology - 1 Jan 2018

Passos Geraldo A, Speck-Hernandez Cesar A, Assis Amanda F, Mendes-da-Cruz Daniella A

Abstract excerpt

Twenty years ago, the autoimmune regulator (Aire) gene was associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, and was cloned and sequenced. Its importance goes beyond its abstract link with human autoimmune disease. Aire identification opened new perspectives to better understand the molecular basis of central tolerance and self-non-self distinction, the main properties of the immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28871661
DOI: 10.1111/imm.12831
PMCID: PMC5721245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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