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Article

[Thymus function and autoimmunity].

La Revue de medecine interne - 1 Aug 2004

Puissant B

Abstract excerpt

PURPOSE: Thymus is the site of T-cell development and is essential for the induction of self-tolerance, by deletion of autoreactive T lymphocytes (negative selection) and by generation of regulatory T cells. Defect of the selection mechanism of both types of lymphocytes lead to autoimmune diseases. CURRENT KNOWLEDGE AND KEY POINTS: Elimination of potentially self-reactive T cells in the thymus requires the...

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Source

Identifiers

PMID: 15276288
DOI: 10.1016/j.revmed.2003.12.017

Genes

AIRE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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