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Article

Lessons on immune tolerance from the monogenic disease APS1.

Current opinion in genetics & development - 1 Jun 2007

DeVoss Jason J, Anderson Mark S

Abstract excerpt

Autoimmunity is a complex disease process that results from a breakdown in the ability of the immune system to discriminate self from non-self. One approach to unraveling how autoimmunity occurs is to study monogenic diseases, for which a single gene defect is responsible. Recent work on the monogenic autoimmune disease 'autoimmune polyglandular syndrome type 1' (APS1) and on the causal gene of this...

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Identifiers

PMID: 17466510
DOI: 10.1016/j.gde.2007.04.001

Genes

AIRE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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