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Article

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.

Scientific reports - 18 Apr 2016

Blaževitš Olga, Mideksa Yonatan G, Šolman Maja, Ligabue Alessio, Ariotti Nicholas, Nakhaeizadeh Hossein, Fansa Eyad K, Papageorgiou Anastassios C, Wittinghofer Alfred, Ahmadian Mohammad R, Abankwa Daniel

Abstract excerpt

Galectin-1 (Gal-1) dimers crosslink carbohydrates on cell surface receptors. Carbohydrate-derived inhibitors have been developed for cancer treatment. Intracellularly, Gal-1 was suggested to interact with the farnesylated C-terminus of Ras thus specifically stabilizing GTP-H-ras nanoscale signalling hubs in the membrane, termed nanoclusters. The latter activity may present an alternative mechanism for how...

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Identifiers

PMID: 27087647
DOI: 10.1038/srep24165
PMCID: PMC4834570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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