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Article

SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling.

Molecular and cellular biology - 15 Oct 2016

Siljamäki Elina, Abankwa Daniel

Abstract excerpt

The Ras/mitogen-activated protein kinase (MAPK) signaling pathway is tightly controlled by negative feedback regulators, such as the tumor suppressor SPRED1. The SPRED1 gene also carries loss-of-function mutations in the RASopathy Legius syndrome. Growth factor stimulation translocates SPRED1 to the plasma membrane, triggering its inhibitory activity. However, it remains unclear whether SPRED1 there acts at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27503857
DOI: 10.1128/MCB.00191-16
PMCID: PMC5038144

Genes

SPRED1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling.PMID 27503857Read ↗

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