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Article

Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation.

Oncogene - 8 Nov 2001

Paz A, Haklai R, Elad-Sfadia G, Ballan E, Kloog Y

Abstract excerpt

Ras genes, frequently mutated in human tumors, promote malignant transformation. Ras transformation requires membrane anchorage, which is promoted by Ras farnesylcysteine carboxymethylester and by a second signal. Previously we showed that the farnesylcysteine mimetic, farnesylthiosalicylic acid (FTS) disrupts Ras membrane anchorage. To understand how this disruption contributes to inhibition of cell...

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Identifiers

PMID: 11709720
DOI: 10.1038/sj.onc.1204950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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