Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

Abstract excerpt

While there have been tremendous efforts to target oncogenic RAS signaling from inside the cell, little effort has focused on the cell-surface. Here, we used quantitative surface proteomics to reveal a signature of proteins that are upregulated on cells transformed with KRAS G12V , and driven by MAPK pathway signaling. We next generated a toolkit of recombinant antibodies to seven of these RAS-induced proteins....

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• Cellular transport and secretion
• Monoclonal and Polyclonal Antibodies Research
• Ubiquitin and proteasome pathways