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Article

An engineered protein antagonist of K-Ras/B-Raf interaction.

Scientific reports - 19 Jul 2017

Kauke Monique J, Traxlmayr Michael W, Parker Jillian A, Kiefer Jonathan D, Knihtila Ryan, McGee John, Verdine Greg, Mattos Carla, Wittrup K Dane

Abstract excerpt

Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to standard therapies. Here we report the engineering of a protein scaffold for preferential binding to K-Ras G12D. This is the first reported inhibitor to achieve nanomolar affinity while exhibiting...

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PMID: 28724936
DOI: 10.1038/s41598-017-05889-7
PMCID: PMC5517481

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