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Article

Unraveling functional significance of natural variations of a human galectin by glycodendrimersomes with programmable glycan surface.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015

Zhang Shaodong, Moussodia Ralph-Olivier, Vértesy Sabine, André Sabine, Klein Michael L, Gabius Hans-Joachim, Percec Virgil

Abstract excerpt

Surface-presented glycans (complex carbohydrates) are docking sites for adhesion/growth-regulatory galectins within cell-cell/matrix interactions. Alteration of the linker length in human galectin-8 and single-site mutation (F19Y) are used herein to illustrate the potential of glycodendrimersomes with programmable glycan displays as a model system to reveal the functional impact of natural sequence variations in...

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Identifiers

PMID: 25902539
DOI: 10.1073/pnas.1506220112
PMCID: PMC4426414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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