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Article

Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target.

Mini reviews in medicinal chemistry - 1 Jan 2016

Chen Mo, Peters Alec, Huang Tao, Nan Xiaolin

Abstract excerpt

The K-, N-, and HRas small GTPases are key regulators of cell physiology and are frequently mutated in human cancers. Despite intensive research, previous efforts to target hyperactive Ras based on known mechanisms of Ras signaling have been met with little success. Several studies have provided compelling evidence for the existence and biological relevance of Ras dimers, establishing a new mechanism for...

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Identifiers

PMID: 26423697
DOI: 10.2174/1389557515666151001152212
PMCID: PMC5421135

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