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Article

APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice.

Current Alzheimer research - 1 Jan 2016

Zhou Meng, Huang Tianwen, Collins Nicole, Zhang Jing, Shen Hui, Dai Xiaoman, Xiao Naian, Wu Xilin, Wei Zhen, York Jason, Lin Lanyan, Zhu Yuangui, LaDu Mary Jo, Chen Xiaochun

Abstract excerpt

APOE4 is the greatest genetic risk factor for Alzheimer's disease (AD), particularly associated with increased levels of amyloid-β (Aβ) and amyloid deposition. However, it remains unclear whether APOE4 is associated with greater tau phosphorylation and neurofibrillary tangle formation, a hallmark of AD leading to structural disruption of the neuronal cytoskeleton. The current study used 3 and 7 month old EFAD...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27087442
DOI: 10.2174/1567205013666160415154550

Genes

CDK5
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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