Article

EPAC2 knockout causes abnormal tau pathology through calpain-mediated CDK5 activation

2022-03-16

Abstract excerpt

Tau pathology, including aberrant tau hyperphosphorylation, aggregation, and mislocalization, is implicated in many neurodegenerative disorders, including Alzheimer’s disease (AD), which is the most prevalent dementia among the elderly. A better understanding of the molecular mechanisms underlying tau pathology should help advance therapies for neurodegenerative diseases. Perturbations in cyclic adenosine monophos...

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Literature Corpus work: 9b195942-5d66-5954-91a9-ff379870fa29
DOI: 10.36922/an.v1i1.8

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