Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2011

He Wei-Qi, Qiao Yan-Ning, Zhang Cheng-Hai, Peng Ya-Jing, Chen Chen, Wang Pei, Gao Yun-Qian, Chen Caiping, Chen Xin, Tao Tao, Su Xiao-Hong, Li Chao-Jun, Kamm Kristine E, Stull James T, Zhu Min-Sheng

Abstract excerpt

Vascular tone, an important determinant of systemic vascular resistance and thus blood pressure, is affected by vascular smooth muscle (VSM) contraction. Key signaling pathways for VSM contraction converge on phosphorylation of the regulatory light chain (RLC) of smooth muscle myosin. This phosphorylation is mediated by Ca(2+)/calmodulin-dependent myosin light chain kinase (MLCK) but Ca(2+)-independent kinases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Muscle, Smooth, Vascular
Share to Myosin-Light-Chain Kinase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Myosin Light Chains

Share to Nephrectomy

Share to Potassium Chloride

Share to Sodium Chloride, Dietary

Share to Vasoconstriction

Share to Vasoconstrictor Agents

Source

Open in PubMed Open full text

Identifiers

PMID: 21572007
DOI: 10.1152/ajpheart.01212.2010
PMCID: PMC3154661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension.PMID 21572007Read ↗

Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice.Semantic proximity Read ↗

Enhanced diastolic dysfunction but preserved systolic function after acute pressure overload in the absence of smoothelin-like 1 proteinSemantic proximity Read ↗

Cardiac myosin light chain is phosphorylated by Ca <sup>2+</sup> /calmodulin-dependent and -independent kinase activitiesSemantic proximity Read ↗

A splice variant of the myosin phosphatase regulatory subunit tunes arterial reactivity and suppresses response to salt loading.Semantic proximity Read ↗

Vascular smooth muscle contraction in hypertension.Semantic proximity Read ↗

The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure.Semantic proximity Read ↗

Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.Semantic proximity Read ↗

Molecular and cellular basis of the regulation of lymphatic contractility and lymphatic absorption.Semantic proximity Read ↗

Differential phosphorylation of LZ+/LZ- MYPT1 isoforms regulates MLC phosphatase activity.Semantic proximity Read ↗

Arterial Myogenic Activation through Smooth Muscle Filamin ASemantic proximity Read ↗

Increased arterial blood pressure and vascular remodeling in mice lacking salt-inducible kinase 1 (SIK1).Semantic proximity Read ↗

Roles of sarcoplasmic reticulum Ca <sup>2+</sup> ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.