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Article

A predisposing effect of HLA class II genes in celiac disease by skewing the naive CD4+ T cell receptor repertoire.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2026

Lindeman Ida, Officer Aengus, Dahal-Koirala Shiva, Risnes Louise F, Hjort Rebecka, Lundin Knut E A, Ness-Jensen Eivind, Watson Corey T, Sollid Ludvig M

Abstract excerpt

Polymorphisms of human leukocyte antigen (HLA) genes confer risks for human diseases. Predisposing effects related to T cell receptor (TCR) recognition of peptide-HLA can be selection of TCR repertoire and/or preferential presentation of disease-driving epitopes. In celiac disease (CeD), HLA-DQ2.5 predisposes by presenting gluten peptides to CD4+ T cells that typically employ stereotyped TCRs. Here, we analyzed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, MHC Class II

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Share to Polymorphism, Genetic

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Share to Receptors, Antigen, T-Cell

Source

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Identifiers

PMID: 42361043
DOI: 10.1073/pnas.2520636123
PMCID: PMC13321128

Genes

CD4
TRA
TRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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