Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of CD74, a putative MIF receptor, in mice enhances osteoclastogenesis and decreases bone mass.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2013

Mun Se Hwan, Won Hee Yeon, Hernandez Paula, Aguila Hector Leonardo, Lee Sun-Kyeong

Abstract excerpt

CD74 is a type II transmembrane protein that can act as a receptor for macrophage migration inhibitory factor (MIF) and plays a role in MIF-regulated responses. We reported that MIF inhibited osteoclast formation and MIF knockout (KO) mice had decreased bone mass. We therefore examined if CD74 wa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, B-Lymphocyte
Share to Macrophage Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophage Migration-Inhibitory Factors

Share to NF-KappaB Inhibitor alpha

Share to NFATC Transcription Factors

Share to RANK Ligand

Share to Tartrate-Resistant Acid Phosphatase

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 23044992
DOI: 10.1002/jbmr.1787
PMCID: PMC3563845

Genes

MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23044992-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of CD74, a putative MIF receptor, in mice enhances osteoclastogenesis and decreases bone mass.PMID 23044992Read ↗

Macrophage Migration Inhibitory Factor (MIF) Supports Homing of Osteoclast Precursors to Peripheral Osteolytic Lesions.Semantic proximity Read ↗

Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.Semantic proximity Read ↗

DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.Semantic proximity Read ↗

MHC Class II Transactivator Is an In Vivo Regulator of Osteoclast Differentiation and Bone Homeostasis Co-opted From Adaptive ImmunitySemantic proximity Read ↗

The KDM4B–CCAR1–MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasisSemantic proximity Read ↗

Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.Semantic proximity Read ↗

p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner.Semantic proximity Read ↗

Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling.Semantic proximity Read ↗

Macrophage migration inhibitory factor (MIF): a promising biomarker.Semantic proximity Read ↗

PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice.Semantic proximity Read ↗

Chemokine receptor 3 is a negative regulator of trabecular bone mass in female mice.Semantic proximity Read ↗

A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.