Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.

Scientific reports - 18 Jan 2016

Watari Kosuke, Shibata Tomohiro, Nabeshima Hiroshi, Shinoda Ai, Fukunaga Yuichi, Kawahara Akihiko, Karasuyama Kazuyuki, Fukushi Jun-Ichi, Iwamoto Yukihide, Kuwano Michihiko, Ono Mayumi

Abstract excerpt

N-myc downstream regulated gene 1 (NDRG1) is a responsible gene for a hereditary motor and sensory neuropathy-Lom (Charcot-Marie-Tooth disease type 4D). This is the first study aiming to assess the contribution of NDRG1 to differentiation of macrophage lineage cells, which has important implications for bone remodeling and inflammatory angiogenesis. Ndrg1 knockout (KO) mice exhibited abnormal curvature of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Bone Remodeling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Dendritic Cells

Share to Macrophages

Share to Neovascularization, Pathologic

Share to Osteoclasts

Share to Osteogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 26778110
DOI: 10.1038/srep19470
PMCID: PMC4726041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.PMID 26778110Read ↗

Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves.Semantic proximity Read ↗

NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease statesSemantic proximity Read ↗

Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing.Semantic proximity Read ↗

Aberrant Neuregulin 1/ErbB Signaling in Charcot-Marie-Tooth Type 4D Disease.Semantic proximity Read ↗

CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization.Semantic proximity Read ↗

The metastasis suppressor, Ndrg-1: a new ally in the fight against cancerSemantic proximity Read ↗

The role of NDRG1 in the pathology and potential treatment of human cancersSemantic proximity Read ↗

Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype.Semantic proximity Read ↗

Macrophage Migration Inhibitory Factor (MIF) Supports Homing of Osteoclast Precursors to Peripheral Osteolytic Lesions.Semantic proximity Read ↗

Macrophage Polarization during MRONJ Development in Mice.Semantic proximity Read ↗

Heterozygous deficiency of delta-catenin impairs pathological angiogenesis.Semantic proximity Read ↗

Cystoid edema, neovascularization and inflammatory processes in the murine Norrin-deficient retinaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.