Article
Increased chemotaxis and activity of circulatory myeloid progenitor cells may contribute to enhanced osteoclastogenesis and bone loss in the C57BL/6 mouse model of collagen-induced arthritis.
Clinical and experimental immunology - 1 Dec 2016
Ikić Matijašević M, Flegar D, Kovačić N, Katavić V, Kelava T, Šućur A, Ivčević S, Cvija H, Lazić Mosler E, Kalajzić I, Marušić A, Grčević D
Abstract excerpt
Our study aimed to determine the functional activity of different osteoclast progenitor (OCP) subpopulations and signals important for their migration to bone lesions, causing local and systemic bone resorption during the course of collagen-induced arthritis in C57BL/6 mice. Arthritis was induced with chicken type II collagen (CII), and assessed by clinical scoring and detection of anti-CII antibodies. We...
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