Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis

Abstract excerpt

Macrophages are activated in inflammation and during early phases of repair processes. Interestingly, they are also present in bone during development, but their function during this process is unclear. Here, we explore the function of macrophages in bone development, growth, and repair using transgenic mice to constitutively or conditionally deplete macrophages. Depletion of macrophages led to early skeletal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone and Joint Diseases
• Share to Bone Metabolism and Diseases
• Share to Immune cells in cancer