Article
Mitochondrial DNA mutations in ageing and cancer.
Molecular oncology - 1 Sept 2022
Smith Anna L M, Whitehall Julia C, Greaves Laura C
Abstract excerpt
Advancing age is a major risk factor for malignant transformation and the development of cancer. As such, over 50% of neoplasms occur in individuals over the age of 70. The pathologies of both ageing and cancer have been characterized by respective groups of molecular hallmarks, and while some features are divergent between the two pathologies, several are shared. Perturbed mitochondrial function is one such...
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