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Article

Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype.

Stroke - 1 Mar 2016

Rutten-Jacobs Loes C A, Traylor Matthew, Adib-Samii Poneh, Thijs Vincent, Sudlow Cathie, Rothwell Peter M, Boncoraglio Giorgio, Dichgans Martin, Meschia James, Maguire Jane, Levi Christopher, Rost Natalia S, Rosand Jonathan, Hassan Ahamad, Bevan Steve, Markus Hugh S

Abstract excerpt

BACKGROUND AND PURPOSE: Elevated plasma homocysteine levels are associated with stroke. However, this might be a reflection of bias or confounding because trials have failed to demonstrate an effect from homocysteine lowering in stroke patients, although a possible benefit has been suggested in lacunar stroke. Genetic studies could potentially overcome these issues because genetic variants are inherited randomly...

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Source

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Identifiers

PMID: 26839351
DOI: 10.1161/STROKEAHA.115.011545
PMCID: PMC4760380

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype.PMID 26839351Read ↗

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