Testing for Hardy-Weinberg equilibrium at biallelic genetic markers on the X chromosome.

doi:10.1038/hdy.2016.20

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Article

Testing for Hardy-Weinberg equilibrium at biallelic genetic markers on the X chromosome.

Heredity - 1 Jun 2016

Graffelman J, Weir B S

Abstract excerpt

Testing genetic markers for Hardy-Weinberg equilibrium (HWE) is an important tool for detecting genotyping errors in large-scale genotyping studies. For markers at the X chromosome, typically the χ(2) or exact test is applied to the females only, and the hemizygous males are considered to be uninformative. In this paper we show that the males are relevant, because a difference in allele frequency between males...

Topics

Chromosomes, Human, X
Female
Gene Frequency
Genetic Markers
Genome-Wide Association Study
Genotype
Genotyping Techniques
Humans
Likelihood Functions
Male
Models, Genetic
Polymorphism, Single Nucleotide
Venous Thrombosis

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Identifiers

PMID: 27071844
DOI: 10.1038/hdy.2016.20
PMCID: PMC4868269

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