Article
CARD14 alterations in Tunisian patients with psoriasis and further characterization in European cohorts.
The British journal of dermatology - 1 Feb 2016
Ammar M, Jordan C T, Cao L, Lim E, Bouchlaka Souissi C, Jrad A, Omrane I, Kouidhi S, Zaraa I, Anbunathan H, Mokni M, Doss N, Guttman-Yassky E, El Gaaied A B, Menter A, Bowcock A M
Abstract excerpt
BACKGROUND: Rare highly penetrant gain-of-function mutations in caspase recruitment domain family, member 14 (CARD14) can lead to psoriasis, a chronic inflammatory disease of the skin and other organs. OBJECTIVES: To investigate the contribution of rare CARD14 variants to psoriasis in the Tunisian population and to expand knowledge of CARD14 variants in the European population. METHODS: CARD14 coding exons were...
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