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Article

A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke.

Molecular psychiatry - 1 Feb 2017

Jensen K P, Smith A H, Herman A I, Farrer L A, Kranzler H R, Sofuoglu M, Gelernter J

Abstract excerpt

Nicotine withdrawal symptoms contribute to relapse in smokers, thereby prolonging the harm caused by smoking. To investigate the molecular basis for this phenomenon, we conducted a genome-wide association study of DSM-IV nicotine withdrawal in a sample of African American (AA) and European American (EA) smokers. A combined AA and EA meta-analysis (n=8021) identified three highly correlated single nucleotide...

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Identifiers

PMID: 27067016
DOI: 10.1038/mp.2016.43
PMCID: PMC5390815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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