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Article

Massive withdrawal symptoms and affective vulnerability are associated with variants of the CHRNA4 gene in a subgroup of smokers.

PloS one - 1 Jan 2014

Lazary Judit, Dome Peter, Csala Iren, Kovacs Gabor, Faludi Gabor, Kaunisto Mari, Dome Balazs

Abstract excerpt

Heterogeneous phenotypes of complex disorders pose a great challenge for genetic association studies and for the development of personalized treatment strategies. Cluster analysis of phenotypic data has been recently proposed as a reliable auxiliary method for such studies. A cohort of 236 treatment-seeking smokers was investigated after overnight nicotine abstinence. Alpha4 nicotinic acetylcholine receptor...

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Share to Genetic Predisposition to Disease
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nicotine

Share to Polymorphism, Single Nucleotide

Share to Receptors, Nicotinic

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Share to Smoking

Share to Substance Withdrawal Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 24498031
DOI: 10.1371/journal.pone.0087141
PMCID: PMC3907445

Genes

CHRNA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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