Article
Identification of candidate genes for nicotine withdrawal in C57BL / 6J × DBA / 2J recombinant inbred mice
13 Feb 2023
Abstract excerpt
Nicotine is the reinforcing ingredient in tobacco. Following chronic exposure, sudden cessation of nicotine use produces negative symptoms of withdrawal that contribute to dependence. The molecular mechanisms underlying nicotine withdrawal behaviors, however, are poorly understood. Using recombinant inbred mice, chronic nicotine was delivered by minipump and withdrawal induced using mecamylamine. Somatic signs of...
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