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Article

Sex‐dependent modulation of age‐related cognitive decline by the L‐type calcium channel gene Cacna1c (Cav1.2)

19 May 2015

Abstract excerpt

Increased calcium influx through L-type voltage-gated calcium channels has been implicated in the neuronal dysfunction underlying age-related memory declines. The present study aimed to test the specific role of Cacna1c (which encodes Cav 1.2) in modulating age-related memory dysfunction. Short-term, spatial and contextual/emotional memory was evaluated in young and aged, wild-type as well as mice with one...

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PMID: 25989111
DOI: 10.1111/ejn.12952

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