Article
Astrocytic abnormalities in brain-specific Cacna1c-deficient mice: Implications for BBB impairment in neuropsychiatric diseases associated with CACNA1C mutations.
Channels (Austin, Tex.) - 1 Dec 2025
Koh Yeojung, Noterman-Soulinthavong Maria, Bangalore Anusha, Kandjoze Uapingena P, Bud Zea, Noel Kamryn L, Lee Hami, Franke Kathryn, Cintrón-Pérez Coral J, Rajadhyaksha Anjali M, Taylor Eric B, Pieper Andrew A
Abstract excerpt
Intronic genetic variants within the CACNA1C gene, which encodes the pore-forming alpha 1c subunit of the Cav1.2 L-type calcium channel, are significant risk factors for a multitude of neuropsychiatric disorders. In most cases, these intronic SNPs have been associated with reduced CACNA1C expression. Here, we demonstrate that targeted genetic deletion of Cacna1c in mouse brain leads to increased astrocyte...
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