Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice.

Oncogene - 18 Feb 1999

Alkhalaf M, Ganguli G, Messaddeq N, Le Meur M, Wasylyk B

Abstract excerpt

The MDM2 proto-oncogene is overexpressed in human tumours and regulates the activities of the tumour suppressors p53 and pRB. We created mice that overexpress MDM2 under the control of the CMV promoter. These mice did not display an increased tumour incidence, but rather a specific skin phenotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 9,10-Dimethyl-1,2-benzanthracene
Share to Carcinogens
Share to Epidermis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-mdm2

Share to Rabbits

Share to Skin Neoplasms

Share to Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 10050879
DOI: 10.1038/sj.onc.1202448

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10050879-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice.PMID 10050879Read ↗

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesisSemantic proximity Read ↗

Mdm proteins: critical regulators of embryogenesis and homoeostasisSemantic proximity Read ↗

Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila.Semantic proximity Read ↗

Distinct downstream targets manifest p53-dependent pathologies in mice.Semantic proximity Read ↗

Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.Semantic proximity Read ↗

The role of MDM2 and MDM4 in breast cancer development and preventionSemantic proximity Read ↗

Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.Semantic proximity Read ↗

MDM2 beyond cancer: podoptosis, development, inflammation, and tissue regeneration.Semantic proximity Read ↗

The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.Semantic proximity Read ↗

Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.Semantic proximity Read ↗

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.Semantic proximity Read ↗

MDM2-A, a common Mdm2 splice variant, causes perinatal lethality, reduced longevity and enhanced senescence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.