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Article

Influence of APOE Gene Polymorphism on Interindividual and Interethnic Warfarin Dosage Requirement: A Systematic Review and Meta-Analysis.

Cardiovascular therapeutics - 1 Oct 2016

Yu Wan-Ying, Sun Xue, Wadelius Mia, Huang Lihua, Peng Chen, Ma Wan-le, Yang Guo-Ping

Abstract excerpt

BACKGROUND: Warfarin is the most extensively used coumarin anticoagulant. It has been shown that the anticoagulant effect of warfarin is associated with genetic variation. Apolipoprotein E (ApoE) is a possible candidate to influence the maintenance dose of warfarin. ApoE affects the vitamin K cycle by mediating the uptake of vitamin K into the liver. The vitamin K cycle is the drug target of warfarin. However,...

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Source

Identifiers

PMID: 27062534
DOI: 10.1111/1755-5922.12186

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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