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Article

Patients with an ApoE epsilon4 allele require lower doses of coumarin anticoagulants.

Pharmacogenetics and genomics - 1 Feb 2005

Visser Loes E, Trienekens Paul H, De Smet Peter A G M, Vulto Arnold G, Hofman Albert, van Duijn Cornelia M, Stricker Bruno H Ch

Abstract excerpt

OBJECTIVE: Vitamin K is an essential cofactor for the synthesis of several blood coagulation factors. It has been suggested that the apolipoprotein E (ApoE) genotype has profound effects on vitamin K status. Therefore, we investigated whether this common genetic polymorphism influenced dose requirements and effects of coumarin anticoagulants. METHODS: We did a cohort study in 1637 patients from an outpatient...

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Source

Identifiers

PMID: 15861030
DOI: 10.1097/01213011-200502000-00002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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