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Article

Genetic determinants of acenocoumarol and warfarin maintenance dose requirements in Slavic population: a potential role of CYP4F2 and GGCX polymorphisms.

Thrombosis research - 1 Sept 2014

Wypasek Ewa, Branicka Agnieszka, Awsiuk Magdalena, Sadowski Jerzy, Undas Anetta

Abstract excerpt

INTRODUCTION: VKORC1 and cytochrome CYP2C9 genetic variants contribute largely to inter-individual variations in vitamin K antagonists (VKAs) dose requirements. Cytochrome P450 4F2 isoform (CYP4F2), gamma-glutamyl carboxylase (GGCX) and apolipoprotein E (APOE) polymorphisms have been suggested to be of minor significance. MATERIALS AND METHODS: We sought to assess the impact of those polymorphisms on dose...

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Source

Identifiers

PMID: 25042728
DOI: 10.1016/j.thromres.2014.06.022

Genes

GGCX
VKORC1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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