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Article

Influence of APOE genotypes and VKORC1 haplotypes on warfarin dose requirements in Asian patients.

British journal of clinical pharmacology - 1 Feb 2008

Lal Suman, Sandanaraj Edwin, Jada Srinivasa Rao, Kong Ming-Chai, Lee Lai-Heng, Goh Boon-Cher, Lee Soo-Chin, Chowbay Balram

Abstract excerpt

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Recent studies on pharmacogenetics of warfarin have implicated apolipoprotein E (APOE) polymorphisms to influence the vitamin K dependent coagulation cascade and hence the efficacy of warfarin. Studies among Caucasian and African Americans showed a significant but conflicting role of apolipoprotein E (APOE) isoforms in warfarin pharmacogenetics. The contribution of APOE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17995970
DOI: 10.1111/j.1365-2125.2007.03053.x
PMCID: PMC2291220

Genes

APOE
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Influence of APOE genotypes and VKORC1 haplotypes on warfarin dose requirements in Asian patients.PMID 17995970Read ↗

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Interethnic variability of warfarin maintenance requirement is explained by VKORC1 genotype in an Asian population.Semantic proximity Read ↗

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