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Article

Influence of polymorphisms in CYP2C9, VKORC1, MDR1 and APOE genes on the warfarin maintenance dose in Brazilian patients.

Pharmacogenomics - 1 Aug 2023

de Freitas Campos Emílio Itamar, Gomes Karina Braga, Ribeiro Daniel Dias, Puurunen Marja Kaarina, Oliveira Magalhães Mourão Aline de, Ferreira Isadora Gonçalves, da Costa Rocha Manoel Otávio, de Souza Renan Pedra, Parreiras Martins Maria Auxiliadora

Abstract excerpt

Background: Polymorphisms in the CYP2C9, VKORC1, MDR1 and APOE genes may impact warfarin dose. Aim: To investigate the influence of sociodemographic, clinical factors and polymorphisms *1, *2 and *3 for CYP2C9, -1639G>A for VKORC1, 3435C>T for MDR1, and ϵ2, ϵ3 and ϵ4 for APOE genes on the mean weekly warfarin maintenance dose in adults. Methods: This cross-sectional study recruited a calculated sample of 315...

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Source

Identifiers

PMID: 37702085
DOI: 10.2217/pgs-2023-0099

Genes

CYP2C9
VKORC1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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