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Article

Molecular Profiling of Acute Myeloid Leukemia in Pakistan: Comprehensive Variant Landscape Revealed by Targeted NGS.

International journal of molecular sciences - 28 Apr 2026

Mahmood Rafia, Khan Saleem Ahmed, Ali Sadia, Sharif Fatima, Khurshid Umar, Ahmed Dilshad, Shahzad Eshal, Malik Hamid Saeed, Asif Naghmi, Jahangir Sidrah

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous malignancy, with clonal complexity and somatic mutations critically influencing prognosis and treatment. While global genomic profiling efforts have revolutionized AML classification and risk stratification, the molecular landscape in Pakistani patients remains underexplored. Our aim is to perform targeted next-generation sequencing (NGS) for somatic mutational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42123510
DOI: 10.3390/ijms27093927
PMCID: PMC13163660

Genes

DNMT3A
IDH1
KIT
NPM1
NRAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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