Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ligand independent aryl hydrocarbon receptor inhibits lung cancer cell invasion by degradation of Smad4.

Cancer letters - 1 Jul 2016

Lee Chen-Chen, Yang Wen-Hao, Li Ching-Hao, Cheng Yu-Wen, Tsai Chi-Hao, Kang Jaw-Jou

Abstract excerpt

The aryl hydrocarbon receptor (AhR) is a ligand-dependent-activated transcriptional factor that regulates the metabolism of xenobiotic and endogenous compounds. Although AhR plays a crucial role in air toxicant-induced carcinogenesis, AhR expression was shown to negatively regulate tumorigenesis. Therefore, in the present study, we investigated the effect of AhR without ligand treatment on cancer invasion in lung...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COP9 Signalosome Complex
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Hydrolases

Share to Receptors, Aryl Hydrocarbon

Share to Smad4 Protein

Share to Snail Family Transcription Factors

Share to Ubiquitination

Share to Vimentin

Source

Identifiers

PMID: 27060206
DOI: 10.1016/j.canlet.2016.03.052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Ligand independent aryl hydrocarbon receptor inhibits lung cancer cell invasion by degradation of Smad4.PMID 27060206Read ↗

Aryl hydrocarbon receptor signaling involved in the invasiveness of LNCaP cells.Semantic proximity Read ↗

Role of the Aryl Hydrocarbon Receptor in Carcinogenesis and Potential as a Drug TargetSemantic proximity Read ↗

The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancersSemantic proximity Read ↗

BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2.Semantic proximity Read ↗

Ah receptor antagonism represses head and neck tumor cell aggressive phenotype.Semantic proximity Read ↗

EMT and CSC-like properties mediated by the IKKβ/IκBα/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes.Semantic proximity Read ↗

Long-isoform NFE2L1 silencing inhibits acquisition of malignant phenotypes induced by arsenite in human bronchial epithelial cells.Semantic proximity Read ↗

Mutations of the Smad2 and Smad4 genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.Semantic proximity Read ↗

A prolonged exposure of human lung carcinoma epithelial cells to benzo[a]pyrene induces p21-dependent epithelial-to-mesenchymal transition (EMT)-like phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.